Transcriptional profiling of single skeletal muscle mononucleated cells coupled with broadband []

Organisation/Company: Università degli Studi di Padova Research Field: Biological sciences » Biology Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 17 Jan 2025 - 09:00 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Background: ME/CFS is a chronic disease affecting over 2 million people in Europe and America, characterized by persistent and unexplained post-exertional fatigue. Its etiology and symptom heterogeneity remain unclear, and no single biomarker or definitive diagnostic sign has been identified. Aim: The project addresses two key questions: a) What pathways are altered in the diverse cell populations of ME/CFS patient muscles? b) How do cellular interactions and communication differ between patient and normal muscles? Methods: The work will integrate impedance sensing, single-cell RNA sequencing, spatial transcriptomics, and pathway analysis to identify differential features, quantitatively explain alterations in ME/CFS patients, and discover new objective markers for diagnosis. Collaborations: The researcher will work within an international group, collaborating with Lehigh University (USA), and the Universities of Chieti and Padova (Italy). J-18808-Ljbffr

Location: it, IT

Posted Date: 1/12/2025