Princ RA/Sr. Principal RA/Associate Scientist/Scientist I, Protein Chemistry

Position Summary:

Protein Chemistry provides expertise in protein design, production, and analytics to support the discovery and early development of bio-therapeutics across disease states. This position will design and execute experiments towards the production of high-quality protein reagents. Furthermore, the position will have responsibilities in developing and implementing protein production technologies.

Who is Omeros?

Omeros is an innovative biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting immunologic disorders including complement-mediated diseases, as well as cancers and addictive and compulsive disorders. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement and is the subject of a biologics license application pending before FDA for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Omeros’ long-acting MASP-2 inhibitor OMS1029 is currently in a Phase 1 multi-ascending-dose clinical trial. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is advancing toward Phase 3 clinical trials for paroxysmal nocturnal hemoglobinuria and complement 3 glomerulopathy. Funded by the National Institute on Drug Abuse, Omeros’ lead phosphodiesterase 7 inhibitor OMS527 is in clinical development for the treatment of cocaine use disorder and, in addition, is being developed as a therapeutic for other addictions as well as for a major complication of treatment for movement disorders. Omeros also is advancing a broad portfolio of novel immuno-oncology programs comprised of two cellular and three molecular platforms. For more information about Omeros and its programs, visit www.omeros.com.

Good things are happening at Omeros!

Come join our Omeros Discovery Team!

Essential Duties & Responsibilities:

• Develops and implements core protein production technologies towards the generation and screening of high-quality protein reagents


• Maintains data integrity with detailed and up-to-date electronic lab notebooks and data documents


• Interprets and presents findings at the group and department level


• Collaboratively guides efforts toward selection of candidate therapeutic modalities in matrix environment

Education, Experience, Skills, and Knowledge Required:

• With a protein sciences focus, minimum education requirements include either a BS degree with a minimum of 3+ years (8+ years) of relevant industry experience; a MS degree with 1+ years (4+ years) of relevant industry experience; a PhD with 0-2 years of relevant experience; (level will be based on relevant years of experience, skills, and knowledge the candidate has)


• Experience applying technical skills towards recombinant protein expression, such as vector construction, use of expression systems (E. coli and HEK) and protein purification (AKTA, Chromatography)


• Experience with determination of protein quality attributes, including purity, size, aggregation state, and endotoxin


• Experience with biophysical and protein analytical techniques such as : UPLC (Reversed Phase, aSEC, aCEX, aHIC), Mass-spec, SPR, or Octet

Behavioral Competencies Required:

• Builds collaborative relationships at the group and interdepartmental levels


• Provides interpretation of production and functional relationship results to help guide selection of therapeutic modalities

Physical Demands Required:

• Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 20 lbs.


• May encounter prolonged periods of sitting or standing


• This position requires working around hazardous materials

Compensation and Benefits

Omeros is proud to offer a competitive total compensation package designed to support the lives of our employees and their families. The wage scale for the Principal RA/Sr. Principal RA/Associate Scientist/Scientist I, Protein Chemistry role is $84,000 - $128,000. Salaries will be determined based on knowledge, skills, education, and experience relevant to the role. Employees are offered medical, dental, vision, life insurance, and a 401(k) plan with a company match. Employees accrue three weeks of vacation and 80 hours of sick time on an annual basis and receive twelve paid holidays throughout the calendar year. This position is eligible for bonus and stock options. To learn more about Omeros, please visit www.omeros.com. 

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skills, and/or abilities required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to hr@omeros.com or contact Omeros, asking for Human Resources, at (206) 676-5000.