Research Scientist, Antibody Discovery & Engineering, In Vivo Based Methods

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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Research Scientist where you will utilize state-of-the-art discovery technology and creating novel treatments to make a large impact on patients’ lives in the fields of Oncology, Gastroenterology and Neuroscience. You will contribute to swift and efficient discovery of biologic therapeutics using in vivo based approaches is the core remit and have a deep scientific engagement and involvement in programs; helping to define the best path forward based on the therapeutic needs, designing immunization strategies, performing immunizations/animal handling and tissue harvest, and conducting HT antibody discovery using technologies using single B cell cloning coupled with NGS. You will also necessitate familiarity with associated screening workflows and data analysis in addition to possessing a sound knowledge of B cell biology, humoral immunity and immunoglobulin genetics and familiarity with basic building block biologics IgG, Fab, sdAb as well as design and optimize lead candidates using display-based technologies (yeast, phage) may also be part of the role. As part of the Biotherapeutic Engineering team, you will report to Senior Director of the team and interface very closely with cross functional project team members to make data driven decisions with impact on pipeline is vital. Here, you will bring strong experience in antibody and biologic discovery to the team and recognize, and streamline for the most efficient ways of working is a high priority in this role, and the role requires tremendous drive, motivation to deliver (and beat) team and program goals, while also pushing the boundaries to enhance discovery and optimization. Working and networking excellently within the team is critical for best performance and team engagement.

How you will contribute:

• Draw on expertise from in vivo based discovery platforms to provide thoughtful guidance on strategies towards candidate profiles for differing target types, including discovery and optimization/ engineering approaches to enhance properties.
• Design and execute immunization strategies including guidance and definition of best immunogen, adjuvant, and immunization routes, conducting immunizations using transgenic mice, while overseeing strategies with other species such as llama.
• Execute hands-on wide array of immunization methodologies autonomously, encompassing protein, cell, and DNA materials, utilizing diverse immunization routes and/or gene gun strategies proficiently.
• Perform animal tissue harvest, B cell separation, and refined enrichment techniques for antigen-specific antibody screening that will include plasma and memory B cell sorting (Beacon and FACS based methods). Perform single-cell RT-PCR, PCR, molecular cloning, and BCR sequence analysis to harvest variable antibody regions for expression and/or repertoire cloning into display platforms, with associated analysis and management of data. Collaborate effectively with high-throughput mammalian expression teams for downstream expression and purification tasks.
• Work closely with NGS discovery team incorporating appropriate and thoughtful analysis throughout the discovery process.
• Prepare and present comprehensive technical or project reports and formal presentations and posters to a broad range of internal/external audiences.
• Interface with cross functional teams, including members from the broader biologics team, disease areas, DMPK and DSRE.
• Remain aware of the competitive landscape in the field through literature .
• Team-centric mindset is key.
• Significantly contribute to the strategies for biologics discovery and engineering of both discovery and final therapeutic modalities.
• Set high standards for effectiveness of execution, efficiency and rigor of thought.

Minimum Requirements/Qualifications:

• PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience.
• Demonstrates theoretical knowledge of discipline in the field of in vivo antibody based antibody discovery.
• Keeps current with emerging trends in discipline

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

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Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

USA - MA - Cambridge

U.S. Base Salary Range:

108,500.00 - 170,500.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsUSA - MA - Cambridge

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

Location: Cambridge, MA, US

Posted Date: 11/17/2024