In Vivo Respiratory Translational Pharmacology Senior Scientist

Date: 23 Sep 2024 Department: Pre-Clinical Team: R&D, Pharmacovigilance & Regulatory Affairs Job Type: Direct Employee Contract Type: Permanent Location: Parma, IT About us Based in Parma, Italy, Chiesi is an international research-focused pharmaceutical and healthcare group with over 85 years’ experience, operating in 31 countries with more than 7,000 employees (Chiesi Group). To achieve its mission of improving people’s quality of life by acting responsibly towards society and the environment, the Group researches, develops and markets innovative drugs in its main therapeutic areas: Discover more here We are proud to be the largest global pharmaceutical group to be awarded B Corp Certification , a recognition of high social and environmental standards . We are a reliable company that adopts and promotes a transparent and ethical behavior at all levels. We believe that the success of Chiesi is built and shaped by our people and our strong set of shared Values and Behaviors . Our people make a critical difference to our success, which is why it is vital that we attract and retain the right talent who will continue to enrich our culture by living and breathing our values and behaviors. In fact, we are a global family made up of different cultures, different genders, generations, ethnicities, abilities, sexual identities and many other enriching diversities. Chiesi Research & Development Our R&D team represents a fundamental asset for the business. It is divided into integrated functional areas focusing on pipeline projects including discovery and preclinical research, global technical development, drug delivery technology, clinical development, regulatory affairs, pharmacovigilance, intellectual property, quality assurance, R&D project and portfolio management. Headquartered in the new purpose-built and fully integrated Research and Development Centre in Parma (Italy), the team also has important operations in Paris (France), Chippenham (UK), Cary (US), Stockholm (Sweden), Toronto (Canada) and Shanghai (China). Who we are looking for Purpose We are seeking a highly motivated and passionate scientist to contribute to our mission in delivering novel therapies for the treatment of chronic respiratory diseases such as asthma, COPD and ILDs. The selected candidate will join our in vivo pharmacology and translational team focused on supporting discovery and translational research activities aimed at characterising novel therapeutic targets and advancing discovery programs to the clinic. Main Responsibilities The person will: Independently design, conduct and analyse experiments to support the identification and/or advancement of clinical candidates, contributing to achieve project goals under tight timelines. Design, execute and analyse key in vivo pharmacology experiments to validate potential therapeutic targets, and understand the biology of novel targets/pathways. Develop and validate novel in vivo models and readouts for respiratory disorders. Set-up and/or perform assays aimed to demonstrate the target engagement and the biological effect through multi-omic approaches of our compounds. Design, coordinate and monitor external studies at CROs. Manage multiple projects at the same time, and work in a fast-paced, cross-functional, and highly collaborative team environment. Act as in vivo subject matter expert in project team meetings. Collaborate with colleagues in other preclinical department such as DMPK and chemistry as well as other functional areas such as clinical and business development. Provide updates at the different research committees and senior management, prepare research reports and peer-reviewed manuscripts, and contribute to the preparation of regulatory documents, and patent filings. Work closely with academic collaborators and outside entities to advance research needs. Stay informed with emerging literature and science in respiratory research. Experience Required At least 3 years of relevant industry experience leading and executing preclinical research for drug discovery. Education PhD degree in biology, immunology, pharmacology or related discipline Languages Fluent in English Italian is not mandatory Technical Skills Demonstrated hands-on experience in in vivo models (experience in respiratory disease models is preferred) to test disease hypotheses and assess drug effects and conducting in vivo studies (certification for in vivo experimentation and animal welfare is mandatory). Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, multi-color flow cytometry, quantitative RT-PCR) in addition to transcriptomics, multi-omics approaches. Knowledge and hands-on experience in studying inflammatory signalling pathways associated to chronic lung disease. Knowledge of common software applications such as Microsoft Office (Excel, PowerPoint, Word) and data analysis software (e.g. GraphPad Prism). Soft Skills Scientific passion and entrepreneurial spirit. Ability to work effectively in a multidisciplinary team environment. Strong organizational skills, self-motivation, flexibility and proactive willingness. Self-awareness and desire to develop your skills further. Ability to work in a team-oriented environment and good communication skills. What we offer You would join a dynamic, fast-growing, challenging and friendly environment. In Chiesi we firmly believe that our people are our most valuable asset , that is why we invest in continuous training, learning and development. Therefore, we strive to continuously promote and satisfy development needs, paying particular attention to the quality of our working environment and to collective well-being. We want our people to come to work happy every day , and we know how important it is to find the right work-life balance in order to be able to give our best. That is why we offer flexible working approach, remote working, support in the relocation process, tax assistance service for foreign colleagues and many other people-care services. J-18808-Ljbffr

Location: Parma, IT

Posted Date: 11/13/2024