GlaxoSmithKline
Senior Scientist - Organic/Medicinal
Job Location
Stevenage, United Kingdom
Job Description
Site Name: UK - Hertfordshire - Stevenage
Posted Date: Oct 21 2024
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.
We are seeking a Senior Scientist in Synthetic Chemistry to join our high throughput experimentation team in Molecular Modalities Capabilities (MMC).
This role is for a laboratory-based chemist carrying out experimental work within GSK's Molecular Modalities Capabilities department. For the successful candidate, this involves deploying medium to ultra high-throughput organic synthesis to generate compounds to test medicinal chemistry hypotheses across a range of modalities, and the development and implementation of new capabilities and technologies to accelerate the drug discovery process and generate high quality reusable data for drug discovery. This is an opportunity to apply your personal expertise in organic synthesis and new chemical technologies to accelerate drug discovery from hit identification to early development (non-GxP).
This position requires an individual with strong synthetic, technical, analytical and personal skills, and a commitment to further personal development as a scientist.
We also seek a Senior Scientist with Bioconjugation experience to join our growing ADC team in Discovery Chemistry.
The Discovery Chemistry group specialises in the design and development of novel approaches for the synthesis of a range of molecular classes, including antibody drug conjugates, to accelerate drug discovery. The team brings together medicinal chemistry, synthetic organic chemistry and automation skills and experience to deliver medicines of the future, uniting science, technology, and talent to get ahead of disease together.
In this role you will:
Role A - Senior Scientist Molecular Modalities Capabilities
Role B - Senior Scientist Discovery Chemistry
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
Role A - Senior Scientist MMC
Role B - Senior Scientist Discovery Chemistry
Closing Date for Applications - Monday 4th November
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive
As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
Location: Stevenage, GB
Posted Date: 10/23/2024
Posted Date: Oct 21 2024
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.
We are seeking a Senior Scientist in Synthetic Chemistry to join our high throughput experimentation team in Molecular Modalities Capabilities (MMC).
This role is for a laboratory-based chemist carrying out experimental work within GSK's Molecular Modalities Capabilities department. For the successful candidate, this involves deploying medium to ultra high-throughput organic synthesis to generate compounds to test medicinal chemistry hypotheses across a range of modalities, and the development and implementation of new capabilities and technologies to accelerate the drug discovery process and generate high quality reusable data for drug discovery. This is an opportunity to apply your personal expertise in organic synthesis and new chemical technologies to accelerate drug discovery from hit identification to early development (non-GxP).
This position requires an individual with strong synthetic, technical, analytical and personal skills, and a commitment to further personal development as a scientist.
We also seek a Senior Scientist with Bioconjugation experience to join our growing ADC team in Discovery Chemistry.
The Discovery Chemistry group specialises in the design and development of novel approaches for the synthesis of a range of molecular classes, including antibody drug conjugates, to accelerate drug discovery. The team brings together medicinal chemistry, synthetic organic chemistry and automation skills and experience to deliver medicines of the future, uniting science, technology, and talent to get ahead of disease together.
In this role you will:
- Develop and realise medicinal/synthetic chemistry plans with high scientific rigour.
- Maintain high laboratory productivity to enable significant and high-quality synthetic contribution to the programmes and platform builds with which you are associated.
- Design, implement, analyse and problem solve as appropriate, with minimal supervision.
Role A - Senior Scientist Molecular Modalities Capabilities
- Work across boundaries to develop and implement best-in-class technological platforms targeted at accelerating the generation of high quality, reusable data for drug discovery.
- Stay up to date with the latest advancements in chemistry and technologies aligned to the group remit and evaluate their potential applications in the discovery of novel therapeutics.
Role B - Senior Scientist Discovery Chemistry
- Develop and implement strategies for efficient and high-quality synthesis, purification, and characterisation of antibody drug conjugates.
- Carry out experimental work within the Discovery Chemistry group. This will involve designing and executing synthetic plans to deliver antibody drug conjugates for biological evaluation. In addition to the laboratory component of this role, this will also involve analysing data, and designing compounds to test medicinal chemistry hypotheses. In contrast to using synthetic organic chemistry to discover new reactions or methodology, this role will involve applying synthesis to discover compounds with improved biological activity.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
- Master's degree (or equivalent) in Chemistry and equivalent experience in a professional industrial setting.
- Ability to understand, interpret and communicate complex scientific data.
- Excellent written and oral communication skills enabling efficient presentation of scientific findings to both technical and non-technical audiences.
Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
- PhD/DPhil (or about to be awarded a PhD/DPhil) in medicinal chemistry/synthetic chemistry/chemical biology/antibody drug conjugates.
Role A - Senior Scientist MMC
- Experience and/or knowledge of the use of novel technologies (e.g. photochemistry, electrochemistry, flow chemistry, high-throughput techniques) in modern organic synthesis, or
- An awareness and understanding of medicinal chemistry principles and their use within a drug discovery setting, or
- Experience with, or an interest in working with, laboratory automation and the development of automation workflows, or
- Experience with, or an interest in working with, data analytics platforms (e.g. Spotfire, PowerBI) and coding (e.g. Python).
Role B - Senior Scientist Discovery Chemistry
- Experience of the conjugation of antibodies to small molecule payloads, including isolation, purification, and characterisation. Experience of conducting sterile workflows is also desired.
- Experience of synthesising and handling highly potent ADC payloads, understanding of the containment and safety protocols required for working with cytotoxic compounds.
Closing Date for Applications - Monday 4th November
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive
As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
Location: Stevenage, GB
Posted Date: 10/23/2024
Contact Information
| Contact | Human Resources GlaxoSmithKline |
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